Gina gill neonatal jaundice index university of british. Original article from the new england journal of medicine the differential diagnosis of jaundice. Jaundice and asymptomatic hyperbilirubinemia are common clinical problems that can be caused by a variety of disorders, including bilirubin overproduction, impaired bilirubin conjugation, biliary obstruction, and hepatic inflammation. At those times adding a different strategy often reveals more conditions. The differential diagnosis of jaundice has changed significantly in the past decade due largely to a sharp decline in the incidence of viral hepatitis types a and b as a result of immunization. Pdf right hypochondrial pain leading to diagnosis of. This was associated with dark urine and loose, lightbrown stools. Common and important causes of obstructive jaundice for doctors and medical students this page is currently being written and will be available soon. Evaluating jaundice laboratory tests direct conjugated and indirect unconjugated bilirubin alkaline phosphatase transaminases amylase cbc. Splenomegaly is a feature of a broad range of diseases, and presents to clinicians in many. Presence of extrahepatic diseases has to be recorded.
Since it is known that an obstructive jaundice which persists for six weeks will be complicated by liver cell degeneration, surgery may finally be necessary in order to determine the cause of the jaundice. Feb 22, 2014 differential diagnosis of icterusjaundice slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Careful patient history and physical examination are essential in the diagnostic process. Common and important causes of jaundice for doctors and medical students this page is currently being written and will be available soon. Young infants are more likely to have congenital anatomic anomalies, such as biliary atresia, or inborn metabolic disorders such as galactosemia. As a guide, monitoring should occur as an inpatient in the presence of liver impairment or significant jaundice and as an outpatient with frequent attendances otherwise. Differential diagnosis of jaundice liver clinical medicine scribd. Get a printable copy pdf file of the complete article 686k, or click on a page image below to browse page by page.
Strategies for generating differential diagnoses a number of different strategies can be used to generate a differential diagnosis. The first critical step is to differentiate intra and extrahepatic cholestasis. Jaundice is not a disease by itself, but rather, a sign that. Animal models suggest that mature breast milk may enhance bilirubin uptake in the gastrointestinal tract, thus increasing enterohepatic circulation and unconjugated bilirubin levels. Background the term jaundice comes from the root jaune, the french word for yellow. Although the presence of jaundice suggests pathology, it is nonspecific. See classification and causes of jaundice or asymptomatic hyperbilirubinemia. Case you are a fourth year medical student studying for your year end exams. Guideline for the investigation of neonatal conjugated. Noninvasive techniques in the diagnosis of jaundiceultrasound and computer.
Identification of best combinations of laboratory tests. With a focused history and physical exam, an accurate diagnosis is possible in approximately 85% of patients. Diagnosis of liver diseases by laboratory results and discriminant analysis. Jaundice occurs by several mechanisms including hemolysis of transfused blood, reabsorptionof a hematoma, hematoperitoneum, sepsis, hypotension, and biliarytract injury. Pancreatitisacuteedema of the head of the pancreas and obstruction of the common bile duct can cause jaundice. The patient with jaundice may be accurately diagnosed through clinical history, physical findings, and noninvasive laboratory and radiologic examinations available in most community hospitals. Usually, the concentration of bilirubin in the blood must exceed 23 mgdl for the coloration to be easily visible. Differential diagnosis indirect unconjugated hyperbilirubinemia. Formulating a differential diagnosis for the advanced practice provider 2nd edition pdf 2018 download section now, in this section of the article, you will be able to get access to the formulating a differential diagnosis for the advanced practice provider 2nd edition pdf 2018 download file in. Kumral a, ozkan h, duman n, yesilirmak dc, islekel h, ozalp y.
Christopher cheung approach to pediatric abdominal pain. He states that this has not occurred in the past, and he. Due to substances in milk that inhibits glucuronyl transferase. Most babies are born with a lot of red blood cells, and because the liver isnt fully developed yet, bilirubin can. Jaundice icterus is the result of accumulation of bilirubin in the bloodstream and subsequent deposition in the skin, sclera, and mucous membranes. Get a printable copy pdf file of the complete article 885k, or click on a page image below to browse page by page. An infant with jaundice without obviously pale stools, who may also have elevated liver enzymes neonatal hepatitis syndrome an infant with jaundice and pale stools suggestive of biliary obstruction or a neonatal cholangiopathy. For the differential diagnosis for jaundice and ruq pain, click here. Cytokines in human colostrum and neonatal jaundice.
Get a printable copy pdf file of the complete article 686k, or click on a page image below. Jaundice may not be clinically evident until serum levels 51 mi. Erythroblastosis fetalis high direct bilirubin in infants who were given intrauterine transfusions. Meinertlimitations and merits of a single serum sample analysis in the differential diagnosis of jaundice. Monitor patients appropriately depending on severity of liver injury. Create a differential diagnosis for conjugated hyperbilirubinemia lets begin. Jaundice is characterized by a yellowish discoloration of tissue most commonly the skin, sclera, and mucosal membranes due to excess deposition of bilirubin. More common causes are listed first, followed by less common causes. History taking and physical examination for the patient with liver disease. The differential diagnosis of intra and extrahepatic. Evaluating jaundice radiologic evaluation confirmation of clinically suspected biliary obstruction by demonstrating intrahepatic andor extrahepatic duct dilation identification of site and cause of the obstruction selection of the appropriate treatment modality for managing the jaundice.
To be updated when it is complete please like us on facebook, follow us on twitter. Jul 30, 2018 neonatal jaundice is a common type of jaundice that happens to newborn babies. Pdf jaundice is not a disease but rather a sign that can occur in many different diseases. Although the clinical features of certain diseases are obvious, some may have more subtle presentations that necessitate a high index of suspicion for diagnosis. Clinical and regulatory protocol for the treatment of jaundice in. It is caused by elevated serum bilirubin levels in the unconjugated or conjugated form. The excess bilirubin causes the skin, eyes, and the mucus membranes in the mouth to turn a. Posthepatic obstruction can be located in several different areas of the biliary tree and can be due to a variety of benign and malignant pathologies outlined below.
Symposium on diseases of the spleen, biliary tract, liver and pancreas the differential diagnosis of jaundice s. Siegenthaler, differential diagnosis in internal medicine isbn97831421418, 2007 georg thieme verlag fever. Normally, serum bilirubin should never exceed 1 to 1. Differential diagnosis of jaundice free download as word doc. Jaundice is a condition that causes skin and the whites of the eyes to turn yellow. However, there may be considerable overlap, and the differential diagnosis is wide. May 21, 2018 the aetiology of breast milk jaundice is not clear. Jaundice is yellowish discoloration of the skin, conjunctiva, and mucous membranes caused by hyperbilirubinemia. Christopher cheung approach to pediatric abdominal.
Jaundice usually occurs because of an underlying condition with the liver that means it cannot dispose of a. Breastfeeding, jaundice and hyperbilirubinemia in the newborn. Bilirubin is a break down product of haemoglobin, manufactured by the reticuloendothelial system mainly in the spleen and bonemarrow but also in any other organs or tissues of the body where. Formulating a differential diagnosis for the advanced. Differential diagnosis for obstructive jaundice oxford. An initial approach to the workup of any liver disease is to determine the acuteness of symptoms. Get a printable copy pdf file of the complete article686k, or click on a page image below to browse page by page. Intrahepatic causes are due to parenchymal liver disease with inability to either. Differential diagnosis jaundice can be caused by a malfunction in any of the three phases of bilirubin production tables 1 and 2. Evaluation guidelines as well as the clinical and regulatory procedures were established for different health care. The differential diagnosis of cholestatic disorders can be wide table 1. In general, the differential diagnoses of jaundice in. Jaundice is a yellow discoloration of body tissues due to an excess of bilirubin, a pigment produced during the metabolism of heme. Medications are another common causes of acute liver injury.
It is in these cases that a diagnosis is often made by clinical experience and keen observation together with laboratory evidence. Laboratory diagnosis of jaundice linkedin slideshare. In studies of inpatients with splenomegaly, haematological diseases were positively associated with lymphadenopathy, massive. Aknowledge of the natural history of bili rubinis essential fortheclear differentiation ofthe different types ofjaundice. It may start as early as 3rd day and reaches peak by 3rd week of life. In studies of inpatients with splenomegaly, haematological diseases were positively associated with lymphadenopathy, massive splenomegaly and cytoses erythrocytosis, leucocytosis, thrombocytosis, marked left shift of the neutrophilic leucocytes or.
If you continue browsing the site, you agree to the use of cookies on this website. Certain strategies work better for different symptoms. In general, jaundice is present when blood levels of bilirubin exceed 3 mgdl. Jaundice consisting of either direct or indirect bilirubin, that is present at birth or appears with in the first 24 hours of life causes. The most common causes of jaundice in the adult population now are decompensation of preexisting chronic liver disease, alcoholic hepatitis, sepsis and abnormal hemodynamic conditions, and gallstone disease. Differential diagnosis of obstructive jaundice springerlink. Full text full text is available as a scanned copy of the original print version. Jaundice is a yellow discoloration of body tissues due to an excess of bilirubin. Wheeler pg, theodossi a, pickford r, laws j, knilljones rp, williams r. Comparative value of serum 5nucleotidase and alkaline phosphatase in the differential diagnosis of jaundice.
Differential diagnosis for jaundice oxford medical education. Levels above 2 mgdl result in detectable jaundice, first in the sclerae, next under the tongue and along the tympanic membranes, and finally in the skin. After generating a differential, you may decide that you would like to expand upon it. Jaundice most often is the result of acute or chronic liver disease, or biliary tract disease, and less commonly the result of hemolytic disorders. To be updated when it is complete please like us on facebook, follow us on twitter or subscribe on youtube using the follow us buttons. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus.
Differential diagnosis differentialdiagnosis oficterus. Full text is available as a scanned copy of the original print version. He denies nv, abdominal pain, po intolerance, fc, recent travel, weight loss. Aug 30, 2011 the differential diagnosis in older children and adolescents however, is very different from infants and neonates and thus will be explored here.
Distinguishing surgical jaundice from medical jaundice is just the first step in the diagnosis and treatment. Wecallthese clusters clinical problems3,4 and include problems of biological, psychological, or sociological origin. Conjugated hyperbilirubinemia in the neonate and young infant. Jaundice may not be clinically evident until serum levels 3 mgdl. Breast milk jaundice correlates with high levels of epidermal growth factor. Pancreatitisacuteedema of the head of the pancreas and obstruction of the common bile. Obstructive jaundice caused by biliary tuberculosis.
Jaundice is a clinical manifestation of diseases involving abnormal bilirubin metabolism, liver dysfunction, andor biliary tract obstruction. Guideline for the investigation of neonatal conjugated jaundice. The causes of jaundice also vary with age, as mentioned above. Taylor, the physiological basis of medical practice ed. Siegenthaler, differential diagnosis in internal medicine. Jaundice is common in the neonatal period, affecting 5060% of newborns. The differential diagnosis of jaundice sciencedirect. Neonatal jaundice background the term jaundice comes from the root jaune, the french word for yellow. Viral hepatitis is the one of the most common causes of acute onset of jaundice. Assessment of jaundice differentials bmj best practice. Ultrasonography is usually the procedure of choice in initial. Evaluating jaundice radiologic evaluation confirmation of clinically suspected biliary.
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